Publications
Publications
2024
2024
Sattler J, Ernst CM, Zweigner J, Hamprecht A. 2024. High frequency of acquired virulence factors in carbapenemase-producing Klebsiella pneumoniae isolates from a large German university hospital, 2013–2021. Antimicrobial Agents and Chemotherapy e00602-24. doi:10.1128/aac.00602-24
2022
2022
Slavetinsky CJ, Hauser JN, Gekeler C, Slavetinsky J, Geyer A, Kraus A, Heilingbrunner D, Wagner S, Tesar M, Krismer B, Kuhn S, Ernst CM, Peschel A. 2022. Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF. eLife 11:1–20. doi:10.7554/elife.66376
Hung DT, Ernst CM, Kawate T. 2022. Compounds, Compositions, And Methods For Inducing Antimicrobial Intracellular Activity And For Preventing And Treating Microbial Infections. WO 2023/086671 A1. Patent. lens.org/lens/patent/004-945-552-019-024
2021
2021
Ma P, He LL, Pironti A, Laibinis HH, Ernst CM, Manson AL, Bhattacharyya RP, Earl AM, Livny J, Hung DT. 2021. Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics. eLife 10:e67310. doi:10.7554/eLife.67310
2020
2020
Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. 2020. Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae. Nature Medicine 26:705–711. doi:10.1038/s41591-020-0825-4
2019
2019
Ernst CM, Peschel A. 2019. MprF-mediated daptomycin resistance. International Journal of Medical Microbiology 0–1. doi:10.1016/j.ijmm.2019.05.010
2018
2018
Ernst CM, Slavetinsky CJ, Kuhn S, Hauser JN, Nega M, Mishra NN, Gekeler C, Bayer AS, Peschel A. 2018. Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance. mBio 9. doi:10.1128/mBio.01659-18
Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML. 2018. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Disease Models & Mechanisms dmm.034876. doi:10.1242/dmm.034876
Ma P, Laibinis HH, Ernst CM, Hung DT. 2018. Carbapenem Resistance Caused by High-Level Expression of OXA-663 β-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate. Antimicrobial Agents and Chemotherapy 62:e01281-18. doi:10.1128/AAC.01281-18
2017
2017
Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O’Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP. 2017. Multi-institute analysis of carbapenem resistance reveals remarkable diversity , unexplained mechanisms , and limited clonal outbreaks. Proceedings of the National Academy of Sciences 114:1–6. doi:10.1073/pnas.1616248114
2015
2015
Ernst CM, Kuhn S, Slavetinsky CJ, Krismer BB, Heilbronner S, Gekeler C, Kraus D, Wagner S, Peschel A. 2015. The Lipid-Modifying Multiple Peptide Resistance Factor Is an Oligomer Consisting of Distinct Interacting Synthase and Flippase subunits. mBio 6:1–9. doi:10.1128/mBio.02340-14
2013
2013
Ernst, Christoph, Peschel, Andreas, Kraus, Alexandra, Tesar, Michael. 2013. Anti-Staphylococcal Antibodies. EP 2935324 B1. Patent. lens.org/lens/patent/103-314-423-091-925
2012
2012
Slavetinsky CJ, Peschel A, Ernst CM. 2012. Alanyl-phosphatidylglycerol and lysyl-phosphatidylglycerol are translocated by the same MprF flippases and have similar capacities to protect against the antibiotic daptomycin in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 56:3492–3497. doi:10.1128/AAC.00370-12
2011
2011
Koprivnjak T, Zhang D, Ernst CM, Pesche a., Nauseef WM, Weiss JP. 2011. Characterization of Staphylococcus aureus cardiolipin synthases 1 and 2 and their Contribution to accumulation of cardiolipin in stationary phase and within phagocytes. Journal of Bacteriology 193:4134–4142. doi:10.1128/JB.00288-11
Andrä J, Goldmann T, Ernst CM, Peschel A, Gutsmann T. 2011. Multiple peptide resistance factor (MprF)-mediated resistance of Staphylococcus aureus against antimicrobial peptides coincides with a modulated peptide interaction with artificial membranes comprising lysyl- phosphatidylglycerol. Journal of Biological Chemistry 286:18692–18700. doi:10.1074/jbc.M111.226886
Ernst CM, Peschel A. 2011. Broad-spectrum antimicrobial peptide resistance by MprF-mediated aminoacylation and flipping of phospholipids. Molecular Microbiology 80:290–299. doi:10.1111/j.1365-2958.2011.07576.x
2010
2010
Sievers S, Ernst CM, Geiger T, Hecker M, Wolz C, Becher D, Peschel A. 2010. Changing the phospholipid composition of Staphylococcus aureus causes distinct changes in membrane proteome and membrane-sensory regulators. Proteomics 10:1685–93. doi:10.1002/pmic.200900772
2009
2009
Ernst CM, Staubitz P, Mishra NN, Yang S-J, Hornig G, Kalbacher H, Bayer AS, Kraus D, Peschel A. 2009. The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion. PLoS pathogens 5:e1000660. doi:10.1371/journal.ppat.1000660